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Rintatolimod

Small molecule · Modulator · developed by AIM ImmunoTech

Phase 3 Most advanced trial
AIM Developer
6 Registered trials

What is Rintatolimod?

Rintatolimod is a synthetic derivative of inosinic acid with immunomodulatory and antiviral properties. It stimulates interferon production, activates the oligoadenylate synthase-RNase L pathway and stimulates natural killer cell activity. It is studied in ovarian cancer, pancreatic cancer, HIV infection, chronic fatigue syndrome and influenza.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
Ampligen, poly I-poly C12U, Poly I:Poly C12U 50 ug
Drug type
Small molecule
Mechanism
Modulator
Pathways
interferon production, oligoadenylate synthase-RNase L pathway, natural killer cell activity
Therapy area
Infectious disease
Developer
AIM ImmunoTech Inc. (AIM)
Also in trials of
AZN
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 3
UNII
94325AJ25N

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT00215800 Phase 3 Chronic Fatigue Syndrome Completed AIM
NCT05927142 Phase 1/2 Metastatic Pancreatic Cancer Active not recruiting AZN
NCT03734692 Phase 1/2 Ovarian Cancer Recurrent Active not recruiting AIM
NCT01591473 Phase 1/2 Influenza, Human Terminated AIM
NCT00035893 Phase 2 HIV Seropositivity Completed AIM
NCT00215813 N/A Chronic Fatigue Syndrome Temporarily not available AIM

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Metastatic Pancreatic CancerOvarian Cancer RecurrentChronic Fatigue SyndromeHIV InfectionHIV SeropositivityInfluenza, HumanMyalgic Encephalomyelitis

More from AIM ImmunoTech

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the AIM page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.