R-oxybutynin · Ditropan, Ditropan Xl

What is R-oxybutynin?

R-oxybutynin is the R-isomer of oxybutynin, the isomer that carries most of the antimuscarinic activity of the racemic mixture. It acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors, relaxing bladder smooth muscle. It is being studied in obstructive sleep apnea, given orally before bed.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as

Ditropan, Ditropan Xl, Gelnique, Oxytrol

Drug type

Small molecule

Targets

muscarinic acetylcholine receptor

Mechanism

Antagonist of muscarinic acetylcholine receptor

Pathways

acetylcholine signaling at postganglionic muscarinic receptors, detrusor smooth muscle relaxation

Therapy area

Respiratory

Developer

Janssen Pharms

In trials of

APMD

FDA status

Approved as Ditropan, Ditropan Xl, Gelnique (July 16, 1975), NDA017577 · FDA label

UNII

5BRQ29UUB7

✅ FDA-approved uses

• Overactive bladder (Oxytrol)

From the indications section of the FDA label (version of May 29, 2024). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Obstructive Sleep Apnea

Sources

• FDA label (DailyMed)
• FDA label Oxytrol (2024-05-29), indications
• ClinicalTrials.gov NCT04580394

Updated Oct 11, 2026.