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Quinidine · Quinidex

Small molecule · Inhibitor of voltage-gated sodium channels and heme polymer (hemazoin) · developed by Wyeth Pharms

Approved FDA, Feb 1962
1 Registered trials

What is Quinidine?

Quinidine is an alkaloid from the Cinchona tree that inhibits voltage-gated sodium channels, reducing sodium influx and slowing impulse conduction in the heart. It also acts within malaria-infected red blood cells by binding heme polymer and preventing its polymerization, leading to parasite death. It is studied in respiratory syncytial virus infection in the context of drug-drug interaction.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
Quinidex
Drug type
Small molecule
Targets
voltage-gated sodium channels, heme polymer (hemazoin)
Mechanism
Inhibitor of voltage-gated sodium channels and heme polymer (hemazoin)
Pathways
sodium influx and cardiac action potential conduction, heme polymerization in the malaria parasite food vacuole
Therapy area
Infectious disease
Developer
Wyeth Pharms Inc
In trials of
ENTA
FDA status
Approved as Quinidex (February 21, 1962), NDA012796

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT06847464 Phase 1 RSV Infection Completed ENTA

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Drug Drug Interaction (DDI)RSV Infection

Sources

Updated Oct 11, 2026.

Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.