Processed Nerve Allograft · Avance Nerve Graft

What is Processed Nerve Allograft?

Processed Nerve Allograft (Avance Nerve Graft) is an acellular nerve scaffold made from human peripheral nerve tissue whose intact endoneurial tubes and basement membrane proteins, including laminin, provide structural and biochemical cues for axonal regeneration. It is used to treat peripheral nerve discontinuities to restore nerve function in the distal tissue.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as

Avance Nerve Graft

Drug type

Other

Pathways

axonal regeneration, Schwann cell migration, neurite extension

Therapy area

Neurology

Developer

Axogen Corporation (AXGN)

FDA status

Approved as Avance Nerve Graft, BLA125816 · FDA label

✅ FDA-approved uses

• Sensory nerve discontinuity (≤25 mm)
• Sensory nerve discontinuity (>25 mm)
• Mixed and motor nerve discontinuity

From the indications section of the FDA label (version of Jan 23, 2026). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Mixed Peripheral Nerve InjuryMotor Peripheral Nerve InjuryPeripheral Nerve DiscontinuityPeripheral Nerve InjuryUpper Extremity Nerve InjuryPeripheral Nerve Discontinuities

Sources

• FDA label (DailyMed)
• FDA label Avance Nerve Graft (2026-01-23), indications
• ClinicalTrials.gov NCT07657182

Updated Oct 11, 2026. Something wrong or missing? Report it on the AXGN page.