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Lyso-Thermosensitive Liposome Doxorubicin

Small molecule · Cytotoxic · developed by Imunon

Phase 3 Most advanced trial (none active)
IMNN Developer
4 Registered trials

What is Lyso-Thermosensitive Liposome Doxorubicin?

Lyso-Thermosensitive Liposome Doxorubicin (ThermoDox) is a temperature-sensitive liposomal formulation of the anthracycline doxorubicin. When activated by external heat (40-41°C), the liposomes release doxorubicin at the tumor site while sparing normal tissues. It is studied in breast cancer, lung cancer, hepatocellular carcinoma, and bone metastases.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
ThermoDox
Drug type
Small molecule
Mechanism
Cytotoxic
Pathways
DNA damage, apoptosis
Therapy area
Oncology
Developer
Imunon (IMNN)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 3

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT02112656 Phase 3 Hepatocellular Carcinoma Completed IMNN
NCT02850419 Phase 2 Breast Cancer Withdrawn IMNN
NCT01640847 Phase 2 Painful Bone Metastases Withdrawn IMNN
NCT02181075 Phase 1 Liver Tumour Completed IMNN

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

AdenocarcinomaBreast CancerBreast CarcinomaHepatocellular CarcinomaLiver TumourNon-small Cell Lung CancerPainful Bone MetastasesSmall Cell Lung Cancer

More from Imunon

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the IMNN page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.