Lidocaine · Lidocaine Hydrochloride And Dextrose, Xylocaine

What is Lidocaine?

Lidocaine is an amide local anesthetic that blocks voltage-gated sodium channels in neuronal cell membranes, inhibiting the initiation and conduction of nerve impulses. Topical and transdermal formulations are studied for pain reduction in conditions such as carpal tunnel syndrome and neck pain.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as

Lidocaine Hydrochloride And Dextrose, Xylocaine, ALGRX-3268, NSC-40030, ZTlido

Drug type

Small molecule

Targets

voltage-gated sodium channels

Mechanism

Inhibitor of voltage-gated sodium channels

Pathways

neuronal impulse conduction

Therapy area

Neurology

Developer

Astrazeneca

In trials of

OMER, SCLX

FDA status

Approved as Lidocaine Hydrochloride And Dextrose, Xylocaine (May 17, 1951), NDA008048 · FDA label

UNII

98PI200987

✅ FDA-approved uses

• Ventricular arrhythmias during cardiac surgery (Lidocaine Hydrochloride And Dextrose)
• Life-threatening ventricular arrhythmias during acute myocardial infarction (Lidocaine Hydrochloride And Dextrose)

From the indications section of the FDA label (version of Jan 19, 2026). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Carpal Tunnel SyndromeHealthyNeck PainNeck Pain, PosteriorPain Reduction

Sources

• FDA label Lidocaine Hydrochloride And Dextrose (2026-01-19), indications
• FDA label (DailyMed)
• NCI Thesaurus
• ClinicalTrials.gov NCT04320173
• ClinicalTrials.gov NCT04320173
• ClinicalTrials.gov NCT04378959
• ClinicalTrials.gov NCT04819581

Updated Oct 3, 2026.