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INO-4500

Vaccine (DNA plasmid) · Immune activation, directed at Lassa virus nucleoprotein · developed by INOVIO PHARMACEUTICALS

Phase 1 Most advanced trial (none active)

INO Developer

1 Registered trials

What is INO-4500?

INO-4500 is a plasmid DNA vaccine administered intradermally for Lassa fever. It is designed to elicit immune responses against Lassa virus antigens.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Vaccine (DNA plasmid)
Targets: Lassa virus nucleoprotein (antigen)
Mechanism: Immune activation, directed at Lassa virus nucleoprotein
Therapy area: Infectious disease
Developer: INOVIO PHARMACEUTICALS (INO)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT04093076	Phase 1	Lassa Fever	Completed	INO

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Lassa Fever

More from INOVIO PHARMACEUTICALS

DNA Plasmid-encoding Interleukin-12 INO-9012/PSA/PSMA DNA Plasmids INO-5150 Phase 1 INO-1400 Phase 1 INO-1401 Phase 1 INO-1800 Phase 1 INO-3106 Phase 1 INO-3107 Phase 1/2 INO-3401 Phase 1 INO-4201 Phase 1 INO-4202 Phase 1 INO-4212 Phase 1 INO-4700 Phase 2 INO-5401 Phase 1/2

Sources

ClinicalTrials.gov NCT04093076

Updated Oct 3, 2026. Something wrong or missing? Report it on the INO page.

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See INO's upcoming FDA decisions, trial readouts, cash runway and dilution risk, updated every day from SEC, FDA and ClinicalTrials.gov filings.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z