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Indibulin · ZIO-301, D-24851

Small molecule · Inhibitor of tubulin · developed by Alaunos Therapeutics

Phase 1/2 Most advanced trial (none active)

TCRT Developer

1 Registered trials

What is Indibulin?

Indibulin is a synthetic small molecule that binds tubulin at a site distinct from taxane and Vinca alkaloid binding sites, destabilizing tubulin polymerization. It induces tumor cell cycle arrest and apoptosis, with activity against multidrug-resistant and taxane-resistant tumor cell lines. It is studied in metastatic breast cancer.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: ZIO-301, D-24851, Zybulin
Drug type: Small molecule
Targets: tubulin
Mechanism: Inhibitor of tubulin
Pathways: microtubule dynamics, cell cycle arrest, apoptosis
Therapy area: Oncology
Developer: Alaunos Therapeutics (TCRT)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1/2
UNII: 80K4H2RB8P

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT01113970	Phase 1/2	Metastatic Breast Cancer	Completed	TCRT

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Metastatic Breast Cancer

More from Alaunos Therapeutics

Ad-RTS-hIL-12 Phase 1/2 Darinaparsin Phase 2 INXN-3001 Phase 1 Palifosfamide Phase 3 Veledimex Phase 1/2

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the TCRT page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z