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Ifinatamab Deruxtecan · DS-7300A

Antibody-drug conjugate · Cytotoxic, directed at B7-homologue 3 (B7-H3, CD276) (CD276) · developed by Merck Sharp & Dohme LLC

Phase 2 Most advanced trial

MRK Developer

1 Registered trials

What is Ifinatamab Deruxtecan?

Ifinatamab deruxtecan is an antibody-drug conjugate composed of a humanized monoclonal antibody against B7-H3 (CD276) conjugated to DXd, a DNA topoisomerase I inhibitor. The antibody targets B7-H3-expressing tumor cells; upon internalization, DXd stabilizes topoisomerase I-DNA complexes, causing DNA breaks and apoptosis. It is studied in lung cancer.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: DS-7300A, I-DXD
Drug type: Antibody-drug conjugate
Targets: B7-homologue 3 (B7-H3, CD276) (CD276), DNA topoisomerase I (TOP1) (secondary target)
Mechanism: Cytotoxic, directed at B7-homologue 3 (B7-H3, CD276) (CD276)
Pathways: DNA replication inhibition, apoptosis
Therapy area: Oncology
Developer: Merck Sharp & Dohme LLC (MRK)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2
UNII: C6I0GC0GX5

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT06780098	Phase 2	Lung Neoplasm	Recruiting	MRK

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Lung Neoplasm

Other drugs acting on CD276

Ac-AKY-2519 Phase 1 GTB-5550 Phase 1

More from Merck Sharp & Dohme LLC

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Sources

NCI Thesaurus

Updated Oct 3, 2026. Something wrong or missing? Report it on the MRK page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z