Heparin · Heparin Sodium, Heparin Sodium In Sodium Chloride

What is Heparin?

Heparin is an anticoagulant derived from animal tissue that binds to antithrombin III, enhancing its ability to inhibit activated coagulation factors, particularly Factor Xa and thrombin. It prevents clot formation by blocking fibrin stabilization and is used to prevent and treat venous thrombosis, pulmonary embolism, and other thromboembolic conditions, as well as to maintain catheter patency.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as

Heparin Sodium, Heparin Sodium In Sodium Chloride, UFH

Drug type

Plasma-derived product

Targets

Antithrombin III (SERPINC1) (binding partner it blocks), Factor Xa (F10) (secondary target), Thrombin (Factor IIa) (F2) (secondary target)

Mechanism

Inhibitor of Antithrombin III (SERPINC1)

Pathways

coagulation cascade, fibrin formation

Therapy area

Renal & urology

Developer

Fresenius Kabi Usa

In trials of

DVA, RMTI

FDA status

Approved as Heparin Sodium, Heparin Sodium In Sodium Chloride (February 22, 1972), NDA017029 · FDA label

🧪 Clinical trials

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Catheter-Related InfectionsEnd Stage Renal DiseaseKidney Failure, Chronic

Sources

• FDA label (DailyMed)
• FDA label Heparin Sodium (2026-08-10), indications
• FDA label Heparin Sodium In Sodium Chloride (2022-01-03), indications
• NCI Thesaurus
• ClinicalTrials.gov NCT02651428
• ClinicalTrials.gov NCT04042324

Updated Oct 3, 2026.