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GEO-CM04S1

Vaccine · Immune activation, directed at SARS-CoV-2 spike protein and SARS-CoV-2 nucleocapsid protein · developed by GeoVax

Phase 2 Most advanced trial
GOVX Developer
2 Registered trials

What is GEO-CM04S1?

GEO-CM04S1 is a vaccine built on a synthetic modified Vaccinia virus Ankara viral vector that encodes the SARS-CoV-2 spike (S) and nucleocapsid (N) proteins. After administration, these antigens are expressed in cells and presented to the immune system, which may activate humoral and cellular responses. It is studied in COVID-19 and in patients with hematologic neoplasms including leukemia, lymphoma and multiple myeloma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type
Vaccine
Targets
SARS-CoV-2 spike protein (antigen), SARS-CoV-2 nucleocapsid protein (antigen)
Mechanism
Immune activation, directed at SARS-CoV-2 spike protein and SARS-CoV-2 nucleocapsid protein
Therapy area
Infectious disease, Oncology
Developer
GeoVax, Inc. (GOVX)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 2

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT04977024 Phase 2 COVID-19 Infection Active not recruiting GOVX
NCT04639466 Phase 1/2 COVID-19 Infection Completed GOVX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Hematopoietic and Lymphoid System NeoplasmLeukemiaLymphomaPlasma Cell MyelomaCOVID-19 Infection

More from GeoVax

Sources

Updated Oct 11, 2026. Something wrong or missing? Report it on the GOVX page.

Follow GOVX, the company behind GEO-CM04S1

See GOVX's upcoming FDA decisions, trial readouts, cash runway and dilution risk, updated every day from SEC, FDA and ClinicalTrials.gov filings.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

This data is for informational purposes only, not investment advice. BioRadar does not provide buy/sell recommendations. Past performance does not guarantee future results. Always do your own due diligence.