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FPI-2053

Bispecific antibody · Antagonist of EGFR and c-Met (MET) · developed by AstraZeneca

Phase 1 Most advanced trial

AZN Developer

1 Registered trials

What is FPI-2053?

FPI-2053 is a humanized bispecific monoclonal antibody that simultaneously binds to EGFR and c-Met on cancer cells. It is being studied in advanced solid tumors including colorectal, head and neck, lung, pancreatic, gastric, and renal cell carcinomas.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Bispecific antibody
Targets: EGFR, c-Met (MET)
Mechanism: Antagonist of EGFR and c-Met (MET)
Pathways: tumor cell proliferation
Therapy area: Oncology
Developer: AstraZeneca (AZN)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT06147037	Phase 1	Advanced Solid Tumor	Active not recruiting	AZN

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Advanced Solid TumorGastric CancerHead and Neck Squamous Cell CarcinomaMetastatic Colorectal CarcinomaNon-small Cell Lung CancerPancreatic Ductal AdenocarcinomaRenal Cell Carcinoma

Other drugs acting on EGFR / MET

Neratinib FDA approved Osimertinib FDA approved Telisotuzumab Vedotin FDA approved Tepotinib FDA approved Actinium Ac 225 FPI-2068 Phase 1 ALX2004 Phase 1 BH-30643 Phase 1/2 CUDC-101 Phase 1 EGFR-TKI inhibitor based on investigator's choice Phase 3 Enozertinib Phase 1/2 Ficerafusp Alfa Phase 2/3 Firmonertinib Phase 3

More from AstraZeneca

Acalabrutinib FDA approved Anifrolumab FDA approved Benralizumab FDA approved Camizestrant FDA approved Durvalumab FDA approved Olaparib FDA approved Tremelimumab FDA approved Actinium Ac 225 FPI-2068 Phase 1 Adavosertib Phase 2 AZD0240 Phase 1 AZD4144 Phase 1 AZD4916 Phase 1

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the AZN page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z