Fluocinolone Acetonide · Derma-Smoothe/Fs, Iluvien

What is Fluocinolone Acetonide?

Fluocinolone acetonide is a corticosteroid. It is used topically for dermatologic inflammatory conditions and as an intravitreal implant for eye disease.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as

Derma-Smoothe/Fs, Iluvien, Synalar, NSC-92339

Drug type

Small molecule

Mechanism

Agonist

Pathways

cellular signaling, immune function, inflammation, protein regulation

Therapy area

Ophthalmology

Developer

Alimera Sciences Inc

In trials of

ANIP

FDA status

Approved as Derma-Smoothe/Fs, Iluvien, Synalar (September 26, 2014), NDA201923 · FDA label

UNII

0CD5FD6S2M

✅ FDA-approved uses

• Psoriasis of the scalp (Derma-Smoothe/Fs)
• Diabetic macular edema (Iluvien)
• Chronic non-infectious uveitis affecting the posterior segment of the eye (Iluvien)

From the indications section of the FDA label (version of Jun 9, 2026). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

UveitisUveitis, AnteriorUveitis, IntermediateUveitis, Posterior

Sources

• FDA label (DailyMed)
• FDA label Derma-Smoothe/Fs (2026-06-09), indications
• FDA label Fluocinolone Acetonide (2026-02-23), indications
• FDA label Iluvien (2026-01-28), indications
• FDA label Synalar (2024-07-18), indications

Updated Oct 11, 2026.