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Firastotug · ADG-116

Monoclonal antibody · Antagonist of CTLA-4 · developed by Adagene

Phase 1 Most advanced trial (none active)

ADAG Developer

1 Registered trials

What is Firastotug?

Firastotug is a human monoclonal antibody that binds CTLA-4 on T cells and blocks its inhibitory signaling, enhancing cytotoxic T-lymphocyte-mediated immune responses against cancer cells. It is being studied in advanced and metastatic solid tumors.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: ADG-116
Drug type: Monoclonal antibody
Targets: CTLA-4
Mechanism: Antagonist of CTLA-4
Pathways: T-cell activation, immune checkpoint inhibition
Therapy area: Oncology
Developer: Adagene Inc (ADAG)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1
UNII: 8B1J60R28A

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT04501276	Phase 1	Advanced/Metastatic Solid Tumors	Completed	ADAG

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Advanced/Metastatic Solid Tumors

Other drugs acting on CTLA4

Ipilimumab FDA approved Tremelimumab FDA approved Botensilimab Phase 2/3 Cadonilimab Early Phase 1 Muzastotug Phase 2 Pembrolizumab/Quavonlimab Phase 1/2 Volrustomig Phase 3 Zalifrelimab Phase 1/2

More from Adagene

ADG106 Phase 1/2 ADG206 Phase 1 Muzastotug Phase 2

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the ADAG page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z