Ferric Citrate · Auryxia

What is Ferric Citrate?

Ferric citrate is an oral ferric iron compound that binds dietary phosphate in the gastrointestinal tract, forming insoluble ferric phosphate that is excreted in the stool. Ferric iron is also reduced in the gut and absorbed, circulating bound to transferrin for incorporation into hemoglobin. It is used in chronic kidney disease for hyperphosphatemia on dialysis and iron deficiency anemia in patients not on dialysis.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as

Auryxia

Drug type

Small molecule

Pathways

iron absorption and transport via transferrin, hemoglobin incorporation

Therapy area

Hematology, Renal & urology

Developer

Keryx Biopharms

In trials of

AKBA

FDA status

Approved as Auryxia (September 5, 2014), NDA205874 · FDA label

✅ FDA-approved uses

• Hyperphosphatemia in Chronic Kidney Disease on Dialysis
• Iron Deficiency Anemia in Chronic Kidney Disease Not on Dialysis
• Hyperphosphatemia in Chronic Kidney Disease on Dialysis
• Iron Deficiency Anemia in Chronic Kidney Disease Not on Dialysis

From the indications section of the FDA label (version of Dec 4, 2024). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Healthy Volunteers

Sources

• FDA label (DailyMed)
• FDA label Auryxia (2024-12-04), indications
• FDA label Ferric Citrate (2024-06-23), indications
• ClinicalTrials.gov NCT04299633

Updated Oct 11, 2026.