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Elritercept · TAK-226, KER-050

Fusion protein · Antagonist of TGF-beta family proteins · developed by TAKEDA PHARMACEUTICAL CO

Phase 3 Most advanced trial
TAK Developer
1 Registered trials

What is Elritercept?

Elritercept is a recombinant fusion protein composed of the ligand-binding domain of activin receptor type IIA linked to the Fc domain of human antibody. It acts as a ligand trap, binding TGF-beta family proteins and blocking their signaling to promote hematopoiesis and increase red blood cell and platelet production. It is studied in myelodysplastic syndrome and anemia.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
TAK-226, KER-050
Drug type
Fusion protein
Targets
TGF-beta family proteins
Mechanism
Antagonist of TGF-beta family proteins
Pathways
hematopoiesis, TGF-beta signaling
Therapy area
Hematology
Developer
TAKEDA PHARMACEUTICAL CO (TAK)
FDA status
Investigational, not approved in the US. Most advanced trial: Phase 3
UNII
ZNC37E4KAK

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT07422480 Phase 3 Myelodysplastic Syndrome Recruiting TAK

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

AnemiaMyelodysplastic Syndrome

More from TAKEDA PHARMACEUTICAL CO

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the TAK page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

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