Doxycycline · Doxycycline Monohydrate

What is Doxycycline?

Doxycycline is a tetracycline-class antibiotic that reversibly binds the bacterial 30S ribosomal subunit and inhibits bacterial protein synthesis. An extended-release formulation (D-PLEX) is studied for preventing surgical site infections.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as

Doxycycline Monohydrate, D-PLEX

Drug type

Small molecule

Targets

bacterial 30S ribosomal subunit

Mechanism

Inhibitor of bacterial 30S ribosomal subunit

Pathways

bacterial protein synthesis inhibition

Therapy area

Infectious disease

Developer

Chartwell Rx

In trials of

PYPD

FDA status

Approved as Doxycycline Monohydrate (December 29, 1989), NDA050641 · FDA label

✅ FDA-approved uses

• Inflammatory lesions of rosacea
• Rocky Mountain spotted fever
• Typhus fever and typhus group
• Q fever
• Rickettsialpox
• Tick fevers
• Respiratory tract infections caused by Mycoplasma pneumoniae
• Lymphogranuloma venereum

From the indications section of the FDA label (version of Apr 15, 2025). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Abdominal SurgeryColon SurgeryPost-Op InfectionSurgical Site Infection

Sources

• FDA label (DailyMed)
• FDA label Doxycycline Monohydrate (2025-07-25), indications
• FDA label Doxycycline (2025-04-15), indications
• NCI Thesaurus
• ClinicalTrials.gov NCT04411199

Updated Oct 3, 2026.