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DNL343

Small molecule · developed by Denali Therapeutics

Phase 2/3 Most advanced trial (none active)

DNLI Developer

2 Registered trials

What is DNL343?

DNL343 is an orally administered agent studied in amyotrophic lateral sclerosis and in healthy volunteers.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Small molecule
Therapy area: Neurology
Developer: Denali Therapeutics Inc. (DNLI)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2/3

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT05842941	Phase 2/3	Amyotrophic Lateral Sclerosis	Completed	DNLI
NCT06281158	Phase 1	Healthy Volunteers	Completed	DNLI

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Amyotrophic Lateral SclerosisHealthy Volunteers

More from Denali Therapeutics

Tividenofusp Alfa FDA approved DNL126 Phase 1/2 DNL201 Phase 1 DNL593 Phase 1/2 DNL628 Phase 1 DNL747 Phase 1 DNL919 Phase 1 DNL921 Phase 1 DNL952 Phase 1

Sources

ClinicalTrials.gov NCT05842941

Updated Oct 11, 2026. Something wrong or missing? Report it on the DNLI page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z