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Cobicistat · Tybost, GS-9350

Small molecule · Inhibitor of cytochrome P450 3A (CYP3A4) · developed by Gilead Sciences

Approved FDA, Sep 2014

GILD Developer

1 Registered trials

What is Cobicistat?

Cobicistat is a mechanism-based inhibitor of cytochrome P450 3A (CYP3A). It increases systemic exposure of the HIV protease inhibitors atazanavir and darunavir when used in combination with other antiretroviral agents for HIV-1 infection treatment in adults and pediatric patients weighing at least 14 kg.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: Tybost, GS-9350
Drug type: Small molecule
Targets: cytochrome P450 3A (CYP3A4)
Mechanism: Inhibitor of cytochrome P450 3A (CYP3A4)
Therapy area: Infectious disease
Developer: Gilead Sciences Inc (GILD)
FDA status: Approved as Tybost (September 24, 2014), NDA203094 · FDA label
UNII: LW2E03M5PG

✅ FDA-approved uses

HIV-1 infection

From the indications section of the FDA label (version of Feb 10, 2026). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT06337032	Phase 4	HIV-1-infection	Recruiting	GILD

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

HIV-1-infection

More from Gilead Sciences

Axicabtagene Ciloleucel FDA approved Bictegravir FDA approved Brexucabtagene Autoleucel FDA approved Bulevirtide FDA approved Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide FDA approved Emtricitabine And Tenofovir Alafenamide FDA approved Emtricitabine/Tenofovir Disoproxil FDA approved Lenacapavir FDA approved Remdesivir FDA approved Sacituzumab Govitecan FDA approved Seladelpar FDA approved Tenofovir Disoproxil FDA approved

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the GILD page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z