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BMS-986504

Small molecule · Inhibitor of PRMT5 · developed by BRISTOL MYERS SQUIBB

Phase 2/3 Most advanced trial

BMY Developer

1 Registered trials

What is BMS-986504?

BMS-986504 is an orally bioavailable PRMT5 inhibitor that selectively targets PRMT5 bound to methylthioadenosine (MTA) in MTAP-deleted cancer cells. By inhibiting PRMT5 methyltransferase activity, it decreases histone methylation, dysregulates RNA splicing, and increases apoptosis specifically in MTAP-deleted tumors. It is being studied in metastatic non-small cell lung cancer with MTAP deletion.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Small molecule
Targets: PRMT5, MTAP deletion (MTAP) (biomarker)
Mechanism: Inhibitor of PRMT5
Pathways: histone methylation, RNA splicing, apoptosis
Therapy area: Oncology
Developer: BRISTOL MYERS SQUIBB (BMY)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2/3
UNII: UHN5PKM648

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT07063745	Phase 2/3	Metastatic Non-small Cell Lung Cancer With MTAP Deletion	Recruiting	BMY

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Metastatic Non-small Cell Lung Cancer With MTAP Deletion

More from BRISTOL MYERS SQUIBB

Apixaban FDA approved Belatacept FDA approved Deucravacitinib FDA approved Ipilimumab FDA approved Lisocabtagene Maraleucel FDA approved Luspatercept FDA approved Mavacamten FDA approved Nab-paclitaxel FDA approved Nivolumab FDA approved Ozanimod FDA approved Relatlimab FDA approved Repotrectinib FDA approved

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the BMY page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z