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Bedoradrine · MN-221

Small molecule · Agonist of beta-2 adrenergic receptor (ADRB2) · developed by MediciNova

Phase 2 Most advanced trial (none active)

MNOV Developer

3 Registered trials

What is Bedoradrine?

Bedoradrine (MN-221) is a small-molecule beta-2 adrenergic receptor agonist administered by intravenous infusion. It is studied in acute asthma, status asthmaticus, and chronic obstructive pulmonary disease.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: MN-221
Drug type: Small molecule
Targets: beta-2 adrenergic receptor (ADRB2)
Mechanism: Agonist of beta-2 adrenergic receptor (ADRB2)
Pathways: cAMP signaling, bronchodilation
Therapy area: Respiratory
Developer: MediciNova (MNOV)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2
UNII: 4EAR229231

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT00838591	Phase 2	Asthma	Completed	MNOV
NCT00683449	Phase 2	Asthma	Terminated	MNOV
NCT01013142	Phase 1	Chronic Obstructive Pulmonary Disease	Completed	MNOV

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

AsthmaChronic Obstructive Pulmonary DiseaseStatus Asthmaticus

Other drugs acting on ADRB2

Albuterol FDA approved Timolol FDA approved

More from MediciNova

Ibudilast Phase 2/3 Tipelukast Phase 2

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the MNOV page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z