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AVT03

Monoclonal antibody · Antagonist of RANKL (TNFSF11) · developed by Alvotech Swiss

Phase 3 Most advanced trial (none active)

ALVO Developer

1 Registered trials

What is AVT03?

AVT03 (denosumab) is a recombinant fully human IgG2 monoclonal antibody that binds RANKL, a protein that drives osteoclast formation and activity. It is given as a subcutaneous injection and is studied in postmenopausal osteoporosis.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Monoclonal antibody
Targets: RANKL (TNFSF11)
Mechanism: Antagonist of RANKL (TNFSF11)
Therapy area: Musculoskeletal
Developer: Alvotech Swiss AG (ALVO)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 3

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT05395091	Phase 3	Osteoporosis, Postmenopausal	Completed	ALVO

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Osteoporosis, Postmenopausal

Other drugs acting on TNFSF11

Denosumab FDA approved

More from Alvotech Swiss

AVT04 Phase 3 AVT05 Phase 3 AVT06 Phase 3 AVT16 Phase 3 AVT29 Phase 3 AVT32-DRL_PB Phase 1 AVT80 Phase 1

Sources

ClinicalTrials.gov NCT05395091

Updated Oct 11, 2026. Something wrong or missing? Report it on the ALVO page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z