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ARCT-154

Vaccine (mRNA vaccine) · Immune activation, directed at SARS-CoV-2 spike protein · developed by Arcturus Therapeutics

Phase 2/3 Most advanced trial (none active)

ARCT Developer

2 Registered trials

What is ARCT-154?

ARCT-154 is a self-amplifying RNA vaccine against SARS-CoV-2, the virus that causes COVID-19. It is studied for prevention of COVID-19 and SARS-CoV-2 infection.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Vaccine (mRNA vaccine)
Targets: SARS-CoV-2 spike protein (antigen)
Mechanism: Immune activation, directed at SARS-CoV-2 spike protein
Therapy area: Infectious disease
Developer: Arcturus Therapeutics, Inc. (ARCT)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2/3

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT05012943	Phase 2/3	COVID-19 Vaccines	Completed	ARCT
NCT05037097	Phase 1/2	COVID-19	Completed	ARCT

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Corona Virus InfectionCOVID-19COVID-19 VaccinesSARS-CoV-2 Infection

More from Arcturus Therapeutics

ARCT-021 Phase 2 ARCT-032 Phase 2 ARCT-165 Phase 1/2 ARCT-2138 Phase 1 ARCT-2303 Phase 3 ARCT-2304 Phase 1/2 ARCT-810 Phase 2

Sources

ClinicalTrials.gov NCT05012943

Updated Oct 11, 2026. Something wrong or missing? Report it on the ARCT page.

Follow ARCT, the company behind ARCT-154

See ARCT's upcoming FDA decisions, trial readouts, cash runway and dilution risk, updated every day from SEC, FDA and ClinicalTrials.gov filings.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z