Amlodipine · Norliqva

What is Amlodipine?

Amlodipine is a dihydropyridine calcium channel blocker that inhibits calcium ion influx into vascular smooth muscle and cardiac muscle, with a greater effect on vascular smooth muscle. It acts as a peripheral arterial vasodilator, lowering peripheral vascular resistance and blood pressure, and relieves angina by reducing myocardial oxygen demand and blocking coronary spasm. It is studied in hypertension.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as

Norliqva

Drug type

Small molecule

Targets

L-type voltage-gated calcium channel

Mechanism

Antagonist of L-type voltage-gated calcium channel

Pathways

calcium influx into vascular smooth muscle and cardiac muscle, peripheral vascular resistance reduction, coronary artery spasm inhibition

Therapy area

Cardiovascular

Developer

Cmp Dev Llc

In trials of

ALNY

FDA status

Approved as Norliqva (February 24, 2022), NDA214439 · FDA label

✅ FDA-approved uses

• Hypertension
• Chronic Stable Angina
• Vasospastic Angina (Prinzmetal's or Variant Angina)
• Angiographically Documented Coronary Artery Disease in patients without heart failure or an ejection fraction <40%

From the indications section of the FDA label (version of Feb 16, 2026). Read the full label for the exact wording, limitations and safety information.

🧪 Clinical trials

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Hypertension

Sources

• FDA label (DailyMed)
• FDA label Norliqva (2026-02-16), indications
• NCI Thesaurus
• ClinicalTrials.gov NCT05103332

Updated Oct 11, 2026.