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Adakitug · BMS-986253, BMS-986253-01

Monoclonal antibody · Antagonist of interleukin-8 (CXCL8) · developed by BRISTOL MYERS SQUIBB

Phase 2 Most advanced trial

BMY Developer

1 Registered trials

What is Adakitug?

Adakitug is a human monoclonal antibody that binds interleukin-8 (IL-8), blocking its interaction with receptors CXCR1 and CXCR2. This inhibits IL-8-mediated signaling and neutrophil activation. It is studied in non-small cell lung cancer and hepatocellular carcinoma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: BMS-986253, BMS-986253-01, anti-IL-8
Drug type: Monoclonal antibody
Targets: interleukin-8 (CXCL8)
Mechanism: Antagonist of interleukin-8 (CXCL8)
Pathways: IL-8-mediated signaling, neutrophil activation and recruitment
Therapy area: Oncology
Developer: BRISTOL MYERS SQUIBB (BMY)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 2
UNII: N0YWS8X3S9

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT04123379	Phase 2	Non-small Cell Lung Cancer	Active not recruiting	BMY

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Hepatocellular CarcinomaNon-small Cell Lung Cancer

More from BRISTOL MYERS SQUIBB

Apixaban FDA approved Belatacept FDA approved Deucravacitinib FDA approved Ipilimumab FDA approved Lisocabtagene Maraleucel FDA approved Luspatercept FDA approved Mavacamten FDA approved Nab-paclitaxel FDA approved Nivolumab FDA approved Ozanimod FDA approved Relatlimab FDA approved Repotrectinib FDA approved

Sources

NCI Thesaurus

Updated Oct 3, 2026. Something wrong or missing? Report it on the BMY page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z