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ABX196 · PBS96

Other · Immune activation, directed at invariant natural killer T cells (iNKT) · developed by Abivax

Phase 1/2 Most advanced trial (none active)

ABVX Developer

1 Registered trials

What is ABX196?

ABX196 is a synthetic glycolipid agonist that activates invariant natural killer T (iNKT) cells. Upon binding, it stimulates iNKTs to recognize CD1d-restricted lipid ligands on tumor cells and secrete cytokines, activating the immune system and enabling direct tumor cell lysis. It is studied in hepatocellular carcinoma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as: PBS96, Obefazimod
Drug type: Other
Targets: invariant natural killer T cells (iNKT), CD1d (secondary target)
Mechanism: Immune activation, directed at invariant natural killer T cells (iNKT)
Pathways: immune activation, cytokine secretion, cytotoxicity
Therapy area: Oncology
Developer: Abivax S.A. (ABVX)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1/2
UNII: SOI87F7GN2

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT03897543	Phase 1/2	Carcinoma, Hepatocellular	Completed	ABVX

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Carcinoma, Hepatocellular

More from Abivax

ABX203 Phase 2/3 Obefazimod Phase 3

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the ABVX page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z