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ABBV-438

Antibody-drug conjugate · Kills target cells, directed at CD38 · developed by AbbVie

Phase 1 Most advanced trial

ABBV Developer

1 Registered trials

What is ABBV-438?

ABBV-438 is an antibody-drug conjugate targeting CD38, a glycoprotein expressed on tumor cells and immune cells. The antibody binds CD38 on tumor cells, leading to cell death through an undisclosed cytotoxic mechanism. It is being studied in multiple myeloma.

Summary written with AI from the sources listed at the end of this page.

At a glance

Drug type: Antibody-drug conjugate
Targets: CD38
Mechanism: Kills target cells, directed at CD38
Therapy area: Oncology
Developer: AbbVie (ABBV)
FDA status: Investigational, not approved in the US. Most advanced trial: Phase 1

🧪 Clinical trials

Trial	Phase	Condition	Status	Sponsor
NCT07409246	Phase 1	Multiple Myeloma	Recruiting	ABBV

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Multiple Myeloma

Other drugs acting on CD38

Felzartamab Phase 3 Mezagitamab Phase 3

More from AbbVie

Adalimumab FDA approved Atogepant FDA approved Pivekimab Sunirine FDA approved Risankizumab FDA approved Telisotuzumab Vedotin FDA approved Upadacitinib FDA approved Venetoclax FDA approved ABBV-1042 Phase 1 ABBV-291 Phase 1 ABBV-295 Phase 2 ABBV-313 Phase 1 ABBV-324 Phase 1

Sources

NCI Thesaurus

Updated Oct 3, 2026. Something wrong or missing? Report it on the ABBV page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z