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A-101 · Eskata, NSC-19892

Small molecule · Cytotoxic · developed by Aclaris

Approved FDA, Dec 2017
ACRS Developer
7 Registered trials

What is A-101?

A-101 is a topical formulation of high-concentration hydrogen peroxide with keratolytic activity. It penetrates skin cells, generates reactive oxygen species, induces oxidative stress and apoptosis to clear affected skin. It is studied for seborrheic keratosis, common warts, and dermatosis papulosa nigra.

Summary written with AI from the sources listed at the end of this page.

At a glance

Also known as
Eskata, NSC-19892
Drug type
Small molecule
Mechanism
Cytotoxic
Pathways
oxidative stress, apoptosis
Therapy area
Dermatology
Developer
Aclaris (ACRS)
FDA status
Approved as Eskata (December 14, 2017), NDA209305
UNII
BBX060AN9V

🧪 Clinical trials

TrialPhaseConditionStatusSponsor
NCT03487588 Phase 4 Seborrheic Keratosis Completed ACRS
NCT03812510 Phase 3 Common Wart Completed ACRS
NCT02667288 Phase 3 Seborrheic Keratosis Completed ACRS
NCT03224598 Phase 2 Dermatosis Papulosa Nigra Completed ACRS
NCT02669862 Phase 2 Common Warts Completed ACRS
NCT02160626 Phase 2 Seborrheic Keratosis Completed ACRS
NCT01986920 Phase 1/2 Seborrheic Keratosis (SK) Completed ACRS

Trials of the companies BioRadar tracks, from ClinicalTrials.gov, most advanced phase first.

Conditions studied

Common WartDermatosis Papulosa NigraSeborrheic KeratosisSeborrheic Keratosis (SK)

More from Aclaris

Sources

Updated Oct 3, 2026. Something wrong or missing? Report it on the ACRS page.

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Data: FDA (Drugs@FDA, Purple Book, DailyMed), NIH (NCI Thesaurus, GSRS, RxNorm), ClinicalTrials.gov • Informational purposes only, not medical or investment advice. • All drugs A–Z

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